Citation

Flaccavento C, Drago A, Pagliuca C, Torrielli MV. Boll. Soc. Ital. Biol. Sper. 1980; 56(9): 912-918.

Vernacular Title

Osservazioni sperimentali sul danno epatico conseguente alla somministrazione di paracetamolo e tetracloruro di carbonio.

Copyright

(Copyright © 1980, Società Italiana di Biologia Sperimentale)

DOI

unavailable

PMID

7448087

Abstract

Preliminary data on the liver damage following combined treatment with paracetamol and carbon tetrachloride in the rat are reported. Administration of a single dose of paracetamol (2000 mg/kg, os) was followed after 1 hour by an intraperitoneal injection of CCl4 (1.0 ml/Kg). Experiments in parallel were performed in rat given paracetamol or CCl4 alone. Our results indicate paracetamol induces a drastic decrease of hepatic GSH that appears in relation with a marked production of TBA-reacting compounds in liver tissue, while CCl4 does not modify the hepatic content of GSH and provokes a slight increase of TBA-reacting substances. Preventive treatment with paracetamol of rats intoxicated after 1 hour with carbon tetrachloride results in a partial protection against fatty liver and necrosis following haloalkane poisoning. On the other hand, the combined treatment with both the hepatotoxins was followed by a minor decrease of GSH. These data are discussed in considering a possible interaction of the two chemicals at the site of their activation.

Language: it