Citation

Stewart MJ, Adriaenssens PI, Jarvie DR, Prescott LF. Ann. Clin. Biochem. 1979; 16(2): 89-95.

Copyright

(Copyright © 1979, Royal Society of Medicine Press)

DOI

unavailable

PMID

37799

Abstract

METHODS for the estimation of plasma paracetamol which depend on acid hydrolysis to p-aminophenol without a prior extraction step also measure inactive metabolites which are present in high concentrations. The extent of the overestimate obtained with such methods was determined using 24 samples from patents after paracetamol overdosage. There was a positive error of between 40 and 700% compared with a high-performance liquid chromatography reference method which measured only unchanged paracetamol. These non-specific methods should not be used to determine the need for specific therapy in patients with paracetamol poisoning.

Language: en