Citation

Franks HM, Hensley VR, Hensley WJ, Starmer GA, Teo RK. Med. J. Aust. 1978; 1(8): 449-452.

Copyright

(Copyright © 1978, Australian Medical Association, Publisher Australasian Medical Publishing)

DOI

unavailable

PMID

351355

Abstract

Thirteen paid student volunteers (9 male, 4 female) were used in a double-blind crossover experiment to investigate the effects of a therapeutic dose of dexchlorpheniramine alone, and in combination with a social dose of ethanol on perceptual, cognitive and motor functions. Both ethanol (0.75 g/kg) and dexchlorpheniramine (4 mg/70 kg) were given orally. Although a synergistic effect of dexchlorpheniramine with ethanol was only observed in some of the tests, a delayed recovery from the effects of the combination was noted. Subjective data indicated that the sedative effects of dexchlorpheniramine were more pronounced in the presence of ethanol.

Language: en