Citation

Stevenson DK, Christie DL, Haas JE. Pediatrics 1978; 61(6): 864-866.

Copyright

(Copyright © 1978, American Academy of Pediatrics)

DOI

unavailable

PMID

673549

Abstract

Trimethoprim-sulfamethoxazole was given to a 16-year-old boy as prophylaxis for a urinary tract infection. He developed severe cholestatic hepatitis 41 days after administration of the drug. A liver biopsy specimen showed a mixed inflammatory infiltrate in the portal triads and prominent bile stasis. The clinical course in this patient supports the concept of an indirect hypersensitivity reaction to sulfamethoxazole.

Language: en