Citation

Niesler U, Palmer A, Radermacher P, Huber-Lang MS. Shock 2014; 42(1): 3-10.

Affiliation

*Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery and † Department of Anesthesiology and Intensive Care, Center for Biomedical Research, University of Ulm, Helmholtzstr. 8/2, 89081 Ulm, Germany.

Copyright

(Copyright © 2014, The Shock Society, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/SHK.0000000000000167

PMID

24667621

Abstract

Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS) can result from both direct and indirect pulmonary damage caused by trauma and shock. In the course of ALI/ARDS, mediators released from resident cells, such as alveolar macrophages, may act as chemoattractants for invading cells and stimulate local cells to build up a pro-inflammatory micro-milieu. Depending on the trauma setting, the role of alveolar macrophages is differentially defined. This review focuses on alveolar macrophage function after blunt chest trauma, ischemia/reperfusion, hemorrhagic shock and thermal burns.

Language: en