Citation

Rump S, Faff J, Borkowska G, Ilczuk I, Rabsztyn T. Arch. Int. Pharmacodyn. Ther. 1978; 232(2): 321-332.

Copyright

(Copyright © 1978, Heymans Institute of Pharmacology)

DOI

unavailable

PMID

677965

Abstract

Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible.

Language: en