Citation

Shishov VI. Farmakol. Toksikol. 1978; 41(2): 230-235.

Vernacular Title

Nekotorye metabolicheskie éffekty étilovogo alkogolia i puti ikh korrektsii.

Copyright

(Copyright © 1978, Izdatelstvo Meditsina)

DOI

unavailable

PMID

26591

Abstract

Tests conducted on albino male-rats demonstrated that with its intragastric administration in a dose of 3 g/kg ethanol produces a hypoxy-like situation in the organism, i.e. the oxygen tension in the liver and skeletal muscles decreases and the redox potential is activation during the 1st hour with succinate-cytochrome-c-oxidase of the liver mitochondria with concomitantly activated oxidation of succinic acid. The activity of NAD-dependent dehydrogenases goes down and in the blood occur acidotic shifts in the acid-base equilibrium (ABE). Twenty four hours after a single administration of ethanol the activity of all the study liver enzymes declines with the acidotic ABE shifts remaining unchanged. The used mixture of glutamate and sodium succinate appreciably decreases the blood ethanol level, corrects metabolic effects of ethanol and increases the survival of rats receiving lethal doses of ethanol.

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