Citation

Ducret F, Zech P, Perrot D, Moskovtchenko JF, Traeger J. Nouv. Presse Med. 1978; 7(1): 27-28.

Vernacular Title

Intoxication volontaire par le propranolol. Evolution des taux sériques.

Copyright

(Copyright © 1978, Masson Editeur)

DOI

unavailable

PMID

662597

Abstract

Suicidal attempt using beta-blockers are rare. Overdose by the ingestion of a large number of tablets rarely exceeds the high therapeutic doses suggested for the treatment of certain resistant cases of hypertension. The case described is that of a 65-year-old patient who took 800 mg of propanolol. Observation of plama levels showed that the half-life propanolol in the case of overdose is prolonged: 8.6 hours in this case, with a maximum plasma level of 1536 ng/ml. Plasma renin activity levels were low during the phase of intoxication and showed evidence of a rebound effect at its end. Treatment is above all that of the circulatory insufficiency produced: isopropylnoradrenaline or glucagon. Indications for extra-renal dialysis should take into account knowledge concerning the pharmacokinetics of these drugs and their prolonged physiological action.

Language: fr