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Citation |
Scott D, Sanders K, Aitken D, Hayes A, Ebeling PR, Jones G. Obesity (Silver Spring) 2014; 22(6): 1568-1574. |
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Affiliation |
NorthWest Academic Centre, The University of Melbourne and Western Health, St Albans, Australia; Australian Institute of Musculoskeletal Science, St Albans, Australia. |
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Copyright |
(Copyright © 2014, Wiley-Blackwell) |
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DOI |
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PMID |
24585708 |
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Abstract |
OBJECTIVES: To determine whether obesity concurrent with sarcopenia (low muscle mass) or dynapenia (low muscle strength) is associated with increased falls risk in middle-aged and older adults. Design and METHODS: Five-year prospective cohort study including 674 community-dwelling volunteers (mean ± SD age 61.4 ± 7.0 years; 48% female). Sarcopenia and dynapenia were defined as lowest sex-specific tertiles for dual-energy X-ray (DXA)-assessed appendicular lean mass (adjusted for height and fat mass) or lower-limb strength, respectively. Obesity was defined as the highest tertiles of DXA-assessed total or trunk fat mass. Change in falls risk was calculated using the Physiological Profile Assessment (z-scores: 0-1 = mild increased risk; 1-2 = moderate increased risk; >2 = marked increased risk). RESULTS: Multivariable linear regression analyses revealed mild but significantly increased falls risk scores for dynapenic obesity (change in mean z-score compared to non-dynapenic, non-obese group: 0.33, 95% CI 0.06 - 0.59 [men] and 0.46, 95% CI 0.21 - 0.72 [women]) and dynapenia (0.25, 95% CI 0.05 - 0.46 [women only]). CONCLUSIONS: Dynapenic obesity, but not sarcopenic obesity, is predictive of increased falls risk score in middle-aged and older adults. In clinical settings, muscle function assessments may be useful for predicting falls risk in obese patients. Language: en |