Citation

Aucamp AK, Weis OF, Müller FO, Gill CE, Malan J. S. Afr. Med. J. 1984; 66(12): 445-446.

Copyright

(Copyright © 1984, South African Medical Association)

DOI

unavailable

PMID

6385309

Abstract

Oxprenolol, a fat-soluble beta-adrenergic blocker, promoted as an anxiolytic agent to alleviate peripheral symptoms associated with anxiety, and lorazepam, a 1,4-benzodiazepine anxiolytic drug, may both depress central nervous system (CNS) function. It is generally accepted that ethanol, when concurrently ingested, potentiates the CNS-depressant effects of drugs. The effects on CNS function of oxprenolol, lorazepam and placebo alone and in combination with ethanol were determined by a Leeds Psychomotor Tester and we concluded that oxprenolol in combination with ethanol is less hazardous to people operating power tools/machines or driving motor vehicles than the combination of lorazepam with ethanol.

Language: en