Citation

Yang C, Ba H, Yu H, Gao Z, Zhao H, Sun J. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2014; 31(1): 101-105.

Affiliation

Psychiatry Department, People Liberation Army 102nd Hospital, Changzhou, Jiangsu 213003, P.R.China. bahuajie@163.com.

Copyright

(Copyright © 2014, Sichuan University)

DOI

10.3760/cma.j.issn.1003-9406.2014.01.024

PMID

24510575

Abstract

OBJECTIVE: To assess the association between aggressive behaviors and 15 short tandem repeats (STRs) loci. METHODS: Peripheral blood samples from 541 army men with aggressive behaviors and 459 healthy individuals were collected. All sample were amplified with a AmpFlSTR Identifiler(TM) system and separated by electrophoresis to compare the genotypic and allelic frequencies of 15 STRs (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, THO1, TPOX and vWA) in the two groups. RESULTS: A significant difference was found in allelic and genotypic frequencies at loci D2S1338 and D19S433 (P< 0.01) between the two groups, but not for the remaining 13 STR loci (P> 0.05). Univarite analysis also showed a significant difference for allele 16, genotypes 19-22, 22-24 on D2S1338 and genotypes 13-14.2 on D19S433 between the two groups (P= 0.0018, P= 0.0001, P= 0.0003, P= 0.0000), with the OR values being 7.380 (95%CI: 1.701-32.028), 0.051(95%CI: 0.007-0.388), 13.933(95%CI: 1.845-105.717), 0.349 (95%CI: 0.216-0.564), respectively. CONCLUSION: D2S1338 and D19S433 may be associated with aggressive behavior. Allele 16 and genotype 22-24 on D2S1338 may be susceptible factors for the disease, whilst genotypes 19-22 on D2S1338 and 13-14.2 on D19S433 may confer a protective effect on it.

Language: zh