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Citation |
Jones AW, Neri A. J. Can. Soc. Forensic Sci. 1991; 24(3): 165-173. |
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Copyright |
(Copyright © 1991, Canadian Society of Forensic Science, Publisher Informa - Taylor and Francis Group) |
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DOI |
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PMID |
unavailable |
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Abstract |
Sixteen healthy men drank 1.43 g ethanol per kg of body weight as Swedish aquavit, export beer, and cognac during 90 min together with a 3-course meal. Capillary (fingertip) blood was drawn on 8 occasions starting at 0-10 min after the end of drinking and blood alcohol concentration (BAC) was determined by an enzymatic method. The peak BAC ranged from 0.97-1.41 mg/ml (mean 1.20 mg/ml) and this occurred 78 min after the end of drinking (range 0-230 min). The mean rate of disappearance of alcohol from blood (β) was 0.16 mg/ml/h (range 0.13-0.21) and the apparent volume of distribution of ethanol was 0.795 l/kg (range 0.64-0.93). The mean rate of ethanol elimination from the body was 128 mg/kg/h (range 99-160). The BAC increased on the average by 0.17 mg/ml (range 0.0-0.45 mg/ml) before reaching the maximum level. During the absorption phase, the BAC had attained on the average 83%, 91%, 95% and 98% of the final peak BAC within 5 min, 45 min, 109 min and 175 min, respectively, after ingestion. These results suggest that part of the dose of alcohol is rapidly absorbed into the blood despite the presence of undigested food in the stomach. However, the absorption of the remaining dose of alcohol might proceed for several hours. |