Citation

Bedrosian TA, Nelson RJ. Curr. Top. Behav. Neurosci. 2013; 17: 131-142.

Affiliation

Department of Neuroscience, The Ohio State University Wexner Medical Center, 636 Biomedical Research Tower, 460 W. 12th Avenue, Columbus, OH, 43210, USA, Bedrosian.2@osu.edu.

Copyright

(Copyright © 2013, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/7854_2013_273

PMID

24368618

Abstract

Violence is a significant public health problem worldwide. Neurobiological research on violence and aggression attempts to elucidate the cellular and molecular pathways that increase the propensity toward this behavior. Research over the past 40 years has implicated several brain regions and neurotransmitters in aggression, mainly using rodent models. Perhaps the strongest association is the link between serotonin and aggression, which has compelling interactions with the nitric oxide system. Recently, new insights into these relationships have been added as modern techniques allow more sophisticated analyses. This chapter will discuss current developments implicating serotonin and nitric oxide in aggressive behavior. Recently developed high-resolution methods for examining the neurobiological basis of aggression will be considered, with emphasis on future directions for the field.

Language: en