Citation

Anckarsäter H, Forsman A, Blennow K. Acta Neurol. Scand. 2005; 112(1): 48-50.

Affiliation

Longitudinal Clinical Psychiatry, Institute of Clinical Sciences, Malmo, Sweden. henrik.anckarsater@skane.se

Copyright

(Copyright © 2005, John Wiley and Sons)

DOI

10.1111/j.1600-0404.2005.00433.x

PMID

15932356

Abstract

OBJECTIVE: To test the hypothesis that cerebrospinal fluid (CSF)/ serum albumin ratios are increased in violent offenders. SUBJECTS AND METHODS: In a previous study of violent offenders, we found significantly higher CSF/serum album ratios (as a sign of increased blood-brain barrier permeability) in violent offenders than in healthy controls. For the present replication study, we recruited a new group of 28 violent offenders, aged 45 years or younger, and 20 new control subjects. RESULTS: The albumin ratio was again significantly higher in the offender group (mean 6.2) than in the control group (mean 4.6) (P = 0.012). Substance abuse or current medication did not appear to explain this finding. CONCLUSION: Increased CSF/serum albumin ratios are an unspecific sign of neurological dysfunction in subgroups of violent offenders.

Language: en