Citation

Soares MJ, Kalberer WD, Erpino MJ. J. Endocrinol. 1977; 73(3): 507-510.

Copyright

(Copyright © 1977, BioScientifica)

DOI

unavailable

PMID

559718

Abstract

The effects of progestagen on elicitation of aggressive behavior in male mice were tested. 48 mice were divided as follows: 1) 16 mice used as pheromone testers; 2) 24 mice bilaterally gonadectomized and subcutaneously implanted with either 20 mg testosterone (T), T + progesterone (P), or control beads; and 3) 8 mice sham-castrated and implanted with control beads. 4 days after the beginning of replacement therapy the treated mice were placed on an 18-hour food deprivation schedule in preparation for olfaction tests. A mouse was considered nonaggressive if response was absent (locating a food pellet) within 5 minutes. Zinc sulphate was administered intranasally to produce a peripheral olfactory dysfunction and produce anosmia. P failed to interfere with the actions of T in the production of aggression-eliciting pheromones and in the maintenance of the preputial and seminal vesicle-coagulating glands. Mice which were only castrated were attacked less than either T-treated or T + P-treated mice.

Language: en