Citation

Wang P, Huang JS, Li XJ, Ma L, Zhou YL, Liao PQ, Wang LH. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2013; 31(10): 765-767.

Affiliation

Department of Occupational Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China.

Copyright

(Copyright © 2013, Tianjin shi lao dong wei sheng yan jiu suo)

DOI

unavailable

PMID

24148956

Abstract

OBJECTIVE: To analyze the clinical features and diagnostic points of occupational acute dimethylformamide (DMF) poisoning and to explore the mechanism of occupational acute DMF poisoning. METHODS: A comprehensive analysis was performed on the clinical data of 16 cases of occupational acute DMF poisoning, including symptoms, signs, and laboratory testing results. RESULTS: The main clinical features of occupational acute DMF poisoning were digestive system impairments, especially abdominalgia. Hemorrhagic gastroenteritis was not found by gastroscopy. There was no significant correlation between the degree of abdominalgia and alanine aminotransferase level (rs = 0.109, P>0.05). CONCLUSION: Abdominalgia is recommended to be one of the reference indices for the diagnosis and degrading of occupational acute DMF poisoning, The mechanism of DMF poisoning remains unclear but it is considered to be related to methyl isocyanate, the intermediate product of DMF metabolism.

Language: zh