Citation

Rokni Yazdi H, Lari S, Attaran D, Ayatollahi H, Mohsenizadeh A. Hum. Exp. Toxicol. 2013; 33(6): 574-581.

Affiliation

Endocrinology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.

Copyright

(Copyright © 2013, SAGE Publishing)

DOI

10.1177/0960327113504973

PMID

24064910

Abstract

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients.

Materials and methods: Thirty nonsmoker mustard lung patients in stable phase were enrolled into this study. Also, 30 COPD and 21 healthy participants were entered as control groups. Complete lung function tests were performed in the participants. The serum levels of adiponectin and leptin were measured in all groups.

RESULTS: There were no statistically significant differences in mean adiponectin and leptin levels among the groups (p = 0.38 and p = 0.35, respectively). There was a downward trend in leptin to adiponectin ratio from lower to higher stages of global initiative for chronic obstructive lung disease guidelines in mustard lung patients, which was not statistically significant (p = 0.8).

CONCLUSION: Our results showed that there is no difference in mean adipokine levels in stable mustard lung patients compared with control groups. There was a foot-point in the alterations of serum adipokines regarding the severity of COPD, which needs to be documented by larger sample group.

Language: en