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Journal Article

Citation

Naudet F, Millet B, Michel Reymann J, Falissard B. Int. J. Methods Psychiatr. Res. 2013; 23(4): 469-473.

Affiliation

INSERM U669, Paris, France; Université de Rennes 1, EA-425 Unité Comportement et Noyaux Gris Centraux, Rennes, France; Centre d'Investigation Clinique CIC-P INSERM 0203, Hôpital de Pontchaillou, Centre Hospitalier Universitaire de Rennes & Université de Rennes 1, Rennes, France.

Copyright

(Copyright © 2013, John Wiley and Sons)

DOI

10.1002/mpr.1393

PMID

24038349

Abstract

Response and remission are determined by the proportion of people who fall below a threshold score on depression rating scales. This calculation implies a possibility of false positives (FP) and false negatives (FN) depending on sensitivity and specificity of the threshold used, but also on response and remission rates. A simulation illustrates the methodological consequences of this phenomenon in a comparative trial where response and remission rates differ between groups: the probability of being misclassified differs between groups, and measures of association (relative risk and odds ratio) are biased. Alternatives are proposed to cope with this misclassification bias. Copyright © 2013 John Wiley & Sons, Ltd.


Language: en

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