Citation

Cequier E, Marcé RM, Becher G, Thomsen C. J. Chromatogr. A 2013; 1310: 126-132.

Affiliation

Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway; Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain. Electronic address: enrique.cequier@fhi.no.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.chroma.2013.08.067

PMID

23992842

Abstract

Emerging flame retardants are used in a great variety of household goods and thus have the potential to pollute our indoor environment. Health concerns regarding exposure to these flame retardants demand new methods to survey their occurrence in humans. This work describes development and optimization of an analytical method comprising solid phase extraction and gas chromatography coupled to mass spectrometry for the determination of besides 15 polybrominated diphenyl ethers, 7 emerging halogenated flame retardants in human serum (1,2-bis[2,4,6-tribromophenoxy] ethane, decabromodiphenyl ethane, hexabromobenzene, Dechlorane Plus(®), hexachlorocyclopentenyl-dibromocyclooctane, dechlorane 602 and 603). The method was thoroughly validated at three spiking levels obtaining averaged recoveries >80% with a RSD of 5% (n=12). Accuracies ranged from 88 to 125% except for DBDPE, which averaged 66% with overall RSD of 11% (n=12). Method limits of detection (MLD) ranged from 0.3 to 5.4pg/mL serum, except for decabromodiphenyl ether and decabromodiphenyl ethane for which MLDs were 14 and 20pg/mL serum, respectively. In human serum samples from Norway, we were able to detect and quantify hexabromobenzene, 1,2-bis[2,4,6-tribromophenoxy] ethane, Dechlorane Plus(®), Dechlorane 602 and 603.

Language: en