Citation

Jerrett M, Burnett RT, Beckerman BS, Turner MC, Krewski D, Thurston G, Martin R, von Donkelaar A, Hughes E, Shi Y, Gapstur SM, Thun MJ, Pope CA. Am. J. Respir. Crit. Care Med. 2013; 188(5): 593-599.

Affiliation

University of California Berkeley, Environmental Health Sciences, Berkeley, California, United States ; jerrett@berkeley.edu.

Copyright

(Copyright © 2013, American Thoracic Society)

DOI

10.1164/rccm.201303-0609OC

PMID

23805824

Abstract

: Rationale: Although substantial scientific evidence suggests that chronic exposure to ambient air pollution contributes to premature mortality, uncertainties exist in the size and consistency of this association. Uncertainty may arise from inaccurate exposure assessment. Objective: To assess the associations of three criteria air pollutants (fine particulate matter, ozone and nitrogen dioxide) with risk of mortality in a large cohort of California adults using individualized exposure assessments. Methods: For fine particulate matter and nitrogen dioxide, we used land use regression models to derive predicted individualized exposure at the home address. For ozone, we estimated exposure with an inverse distance weighting interpolation. Standard and multilevel Cox survival models were used to assess the association between air pollution and mortality. Measurements: Data for 73,711 subjects that resided in California were abstracted from the American Cancer Society Cohort Cancer Prevention II Cohort, with baseline ascertainment of individual characteristics in 1982 and follow up of vital status through to 2000. Exposure data were derived from government monitors. Results: Exposure to fine particulate matter, ozone and nitrogen dioxide were all positively associated with ischemic heart disease mortality. Nitrogen dioxide (a marker for traffic pollution) and fine particulate matter were also associated with mortality from all causes combined. Only nitrogen dioxide had significant positive association with lung cancer mortality.

Language: en