Citation

Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM, Manley GT, McKee A, Petersen RC, Pitman RK, Yaffe KC, Zetterberg H, Obana R, Bain LJ, Carrillo MC. Alzheimers Dement. 2013; 9(4): 445-451.

Affiliation

San Francisco Veterans Administration Medical Center, San Francisco, CA, USA; University of California, San Francisco, CA, USA.

Copyright

(Copyright © 2013, Alzheimer's Association, Publisher Elsevier Publishing)

DOI

10.1016/j.jalz.2013.03.005

PMID

23809365

Abstract

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

Language: en