Citation

Wechsberg WM, Jewkes R, Novak SP, Kline T, Myers B, Browne FA, Carney T, Morgan Lopez AA, Parry C. BMJ Open 2013; 3(5): 2013-002622.

Affiliation

Substance Abuse Treatment Evaluations and Intervention Research, RTI International, Durham, North Carolina, USA.

Copyright

(Copyright © 2013, BMJ Publishing Group)

DOI

10.1136/bmjopen-2013-002622

PMID

23793683

Abstract

OBJECTIVE: To assess the impact of the Women's Health CoOp (WHC) on drug abstinence among vulnerable women having HIV counselling and testing (HCT). DESIGN: Randomised trial conducted with multiple follow-ups. SETTING: 15 communities in Cape Town, South Africa. PARTICIPANTS: 720 drug-using women aged 18-33, randomised to an intervention (360) or one of two control arms (181 and 179) with 91.9% retained at follow-up. INTERVENTIONS: The WHC brief peer-facilitated intervention consisted of four modules (two sessions), 2 h addressing knowledge and skills to reduce drug use, sex risk and violence; and included role-playing and rehearsal, an equal attention nutrition intervention, and an HCT-only control. PRIMARY OUTCOME MEASURES: Biologically confirmed drug abstinence measured at 12-month follow-up, sober at last sex act, condom use with main and casual sex partners, and intimate partner violence. RESULTS: At the 12-month endpoint, 26.9% (n=83/309) of the women in the WHC arm were abstinent from drugs, compared with 16.9% (n=27/160) in the Nutrition arm and 20% (n=31/155) in the HCT-only control arm. In the random effects model, this translated to an effect size on the log odds scale with an OR of 1.54 (95% CI 1.07 to 2.22) comparing the WHC arm with the combined control arms. Other 12-month comparison measures between arms were non-significant for sex risk and victimisation outcomes. At 6-month follow-up, women in the WHC arm (65.9%, 197/299) were more likely to be sober at the last sex act (OR1.32 (95% CI 1.02 to 1.84)) than women in the Nutrition arm (54.3%, n=82/152). CONCLUSIONS: This is the first trial among drug-using women in South Africa showing that a brief intervention added to HCT results in greater abstinence from drug use at 12 months and a larger percentage of sexual activity not under the influence of substances. TRIAL REGISTRATION NUMBER: NCT00729391 ClinicalTrials.gov.

Language: en