Citation

Schilling A, Corey R, Leonard M, Eghtesad B. Cleve. Clin. J. Med. 2010; 77(1): 19-27.

Affiliation

Department of Pharmacy, JJN1-02, Cleveland Clinic, Cleveland, OH 44195, USA. schilla2@ccf.org

Copyright

(Copyright © 2010, Cleveland Clinic Educational Foundation)

DOI

10.3949/ccjm.77a.09084

PMID

20048026

Abstract

The US Food and Drug Administration (FDA), concerned about the incidence of acute liver failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on acetaminophen packaging. It is also considering (but has not enacted) reducing the maximum daily dose from 4 g (possibly to 3,250 mg), banning acetaminophen-narcotic combination products, and changing the current maximum single dose of 1 g to prescription status, making 650 mg the highest recommended nonprescription dose. We review the epidemiology, toxicology, and management of acetaminophen overdose and steps the FDA and physicians can take to prevent it.

Language: en