Citation

Kubzansky LD. Cleve. Clin. J. Med. 2011; 78(Suppl 1): S65-S68.

Affiliation

Department of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Kresge Building, Room 714, Boston, MA 02115, USA. lkubzans@hsph.harvard.edu

Copyright

(Copyright © 2011, Cleveland Clinic Educational Foundation)

DOI

10.3949/ccjm.78.s1.11

PMID

21972334

Abstract

Previous research has demonstrated an association between depression and incident coronary heart disease (CHD); in 2010, well-controlled studies and meta-analyses went beyond depression to include anxiety, anger expression, and negative affect as predictors of incident CHD. Emerging research suggests that positive emotions and resilience (including the ability to self-regulate) offer protection against CHD. New research is elucidating the pathophysiology to explain the effects of emotion and resilience on disease risk; for example, recent work has begun to consider how the relaxation response promotes resilience and found that it induces genomic changes that counter oxidative stress and associated cellular damage.

Language: en