Citation

Eva G, Anke-Maria K, Kaitlen H, Marion A, Lydia B, Jürgen H, Ralf J, Eberhardt K, Ulrich M, Friedemann M, Thomas M, Dennis N, Matthias S, Andreas S, Andreas B. Arch. Phys. Med. Rehabil. 2013; 94(10): 1870-1876.

Affiliation

Institute of Medical Information Processing, Biometry and Epidemiology, University of Munich, Germany; Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders (IFB(LMU)), University of Munich, Germany.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.apmr.2012.10.040

PMID

23732165

Abstract

OBJECTIVE: To describe rationale and design of a new patient registry (KOPF-R, Koma Outcome von Patienten der Frührehabilitation) which has the scope to examine determinants of long-term outcome and functioning of patients with severe disorders of consciousness (DOC) . DESIGN: Prospective multicenter neurological rehabilitation registry SETTING: Five specialized neurological rehabilitation facilities PARTICIPANTS: Patients with DOC in vegetative state (VS) or minimally conscious state (MCS) as defined by the coma recovery scale-revised (CRS-R) following brain injury INTERVENTIONS: n/a MAIN OUTCOME MEASURES: Coma Recovery Scale-Revised (CRS-R), Functional Independence Measure (FIM), emergence from MCS RESULTS: The registry was set up in five facilities across the state of Bavaria/Germany with a special expertise in the rehabilitation of acquired brain injury. Inclusion of patients started in August 2011. Measures include sociodemographic and clinical characteristics, course of acute therapy, electrophysiological measures (evoked potentials, electroencephalogram, EEG), neuron specific enolase (NSE), current medication, functioning, cognition, participation, quality of life, quantity and characteristics of rehabilitation therapy, caregiver burden, and attitudes towards end-of-life decisions. By end of January 2012, 42 patients (38% female) with a mean age of 57 years (standard deviation SD 16) were enrolled. Main diagnoses were traumatic brain injury (TBI, 24%), intracerebral or subarachnoid hemorrhage (IAH/SAH, 31%), and anoxic-ischemic encephalopathy (AIE, 45%). Mean CRS-R score at admission to rehabilitation was 5.9 (SD 3.3), mean FIM score at admission was 18 (SD 0.4). CONCLUSIONS: The KOPF-registry aspires to contribute prospective data on prognosis in severe DOC.

Language: en