Citation

Mauger AR, Hopker JG. Can. J. Physiol. Pharmacol. 2013; 91(2): 187-189.

Affiliation

Endurance Research Group, School of Sport and Exercise Sciences, Faculty of Science, University of Kent, Kent, England.

Copyright

(Copyright © 2013, National Research Council of Canada)

DOI

10.1139/cjpp-2012-0213

PMID

23458204

Abstract

Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.

Language: en