Citation

Amieva H, Rouch-Leroyer I, Letenneur L, Dartigues JF, Fabrigoule C. Brain Cogn. 2004; 54(3): 212-214.

Affiliation

INSERM U593, Université de Bordeaux II, Bordeaux, France. helene.amieva@isped.u-bordeaux2.fr

Copyright

(Copyright © 2004, Elsevier Publishing)

DOI

10.1016/j.bandc.2004.02.003

PMID

15050776

Abstract

Alzheimer's disease produces a generalized slowing of cognitive processing increasing with the progression of dementia. However little is known about this phenomenon in the pre-demented stages. Our purpose was to investigate cognitive slowing in pre-demented subjects and their ability to develop target detection skills while performing a cancellation task. The results on 16 pre-demented subjects and 32 matched controls show that cognitive slowing is already present 3 years before subjects fulfill dementia criteria, at a stage where errors are still not different between pre-demented and control subjects. Additionally, the two groups significantly improved their time performances all along the test suggesting that both groups including the pre-demented group were able to progressively acquire a target detection skill.

Language: en