Citation

Miret M, Ayuso-Mateos JL, Sánchez-Moreno J, Vieta E. Neurosci. Biobehav. Rev. 2013; 37(10 Pt 1): 2372-2374.

Affiliation

Department of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2013.01.008

PMID

23313644

Abstract

The social and economic impact of mood disorders and suicide is extremely high and may be even higher in coming years, and yet, research in mental health is largely underfunded. This report summarizes the most recent data concerning the epidemiology and burden of depression and suicide, and underlines the most recent initiatives to identify the barriers to effective treatment and prevention of mood disorders. Global cooperation and networks of research networks are proposed. Progress in the understanding of the pathophysiology and subtypes of depression, technological advances, emphasis on early prediction of response and prevention, and a paradigm shift in drug development are crucial to overcome the current challenges posed by increasing rates of depression and suicide.

Language: en