Citation

Kuperman S, Chan G, Kramer JR, Wetherill L, Bucholz KK, Dick D, Hesselbrock V, Porjesz B, Rangaswamy M, Schuckit MA. Pediatrics 2013; 131(2): 242-248.

Affiliation

Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa;

Copyright

(Copyright © 2013, American Academy of Pediatrics)

DOI

10.1542/peds.2012-0880

PMID

23296431

Abstract

OBJECTIVE:With the use of a new cohort of adolescent subjects, predictors from the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) interview and the Achenbach Youth Self Report (YSR) were combined to model age of first drink (AFD).METHODS:Subjects consisted of 820 adolescents (ages 14-17) drawn from the current phase of the Collaborative Study on the Genetics of Alcoholism. Three Cox proportional hazards models were considered. Model 1 contained SSAGA variables equivalent to AFD predictors from our previous study: interview age, family history of alcohol dependence, and number of conduct disorder symptoms. Model 2 incorporated 2 additional SSAGA questions (best friends drink and smoked a cigarette before a reported AFD) plus 8 YSR-derived scale scores. Model 3 was a reduced version of model 2, retaining only significant predictors.RESULTS:Model 2 was a significant improvement over model 1. Model 3 was the best and the most parsimonious of the 3 with respect to likelihood ratio and Wald χ(2) tests and retained only 5 variables from model 2. Included variables were the following: (1) best friends drink, (2) membership in a high-risk alcohol dependence family, (3) number of conduct disorder symptoms, (4) YSR externalizing score, and (5) YSR social problems score.CONCLUSIONS:Adding variables to those from our original study improved our ability to model the likely age of alcohol initiation. In addition to the SSAGA, the YSR appears to have utility as a research tool to predict the age of alcohol initiation.

Language: en