Citation

Sasaki K, Wakui K, Tsutsumi K, Itoh A, Date H. Comput. Math. Methods Med. 2012; 2012: 389095.

Affiliation

Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.

Copyright

(Copyright © 2012, Hindawi Publishing)

DOI

10.1155/2012/389095

PMID

23197991

Abstract

The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5.

Language: en