Citation

Moretti L, Cristofori I, Weaver SM, Chau A, Portelli JN, Grafman J. Lancet Neurol. 2012; 11(12): 1103-1112.

Affiliation

Traumatic Brain Injury Research Laboratory, Kessler Foundation, West Orange, NJ, USA.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/S1474-4422(12)70226-0

PMID

23153408

Abstract

Traumatic brain injury (TBI) is an important public health problem with potentially serious long-term neurobehavioural sequelae. There is evidence to suggest that a history of TBI can increase a person's risk of developing Alzheimer's disease. However, individuals with dementia do not usually have a history of TBI, and survivors of TBI do not invariably acquire dementia later in life. Instead, a history of traumatic brain injury, combined with brain changes associated with normal ageing, might lead to exacerbated cognitive decline in older adults. Strategies to increase or maintain cognitive reserve might help to prevent exacerbated decline after TBI. Systematic clinical assessment could help to differentiate between exacerbated cognitive decline and mild cognitive impairment, a precursor of Alzheimer's disease, with important implications for patients and their families.

Language: en