Citation

Martinez-Vargas M, Rojo FE, Tabla-Ramon E, Navarro-Argüelles H, Ortiz-Lailzon N, Hernández-Chávez A, Solis B, Tapia RM, Arredondo AP, Morales-Gomez J, Gonzalez-Rivera R, Nava-Talavera K, Navarro L. Neurosci. Lett. 2012; 529(2): 118-122.

Affiliation

Depto. Fisiologia Facultad de Medicina, Universidad Nacional Autonoma de Mexico. Apdo. Postal 70-250, Mexico, D.F. 04510, Mexico.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.neulet.2012.09.037

PMID

23022503

Abstract

During the process of a brain injury, responses to produce damage and cell death are activated, but self-protective responses that attempt to maintain the integrity and functionality of the brain are also activated. We have previously reported that the recovery from a traumatic brain injury (TBI) is better in rats if it occurs during the dark phase of the diurnal cycle when rats are in the waking period. This suggests that wakefulness causes a neuroprotective role in this type of injury. Here we report that 24 h of total sleep deprivation after a TBI reduces the morphological damage and enhances the recovery of the rats, as seen on a neurobiological scale.

Language: en