Citation

Altura BM, Carella A, Gebrewold A. Int. J. Clin. Exp. Med. 2012; 5(4): 289-295.

Affiliation

Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center Brooklyn, New York 11203, USA ; Department of Medicine, State University of New York, Downstate Medical Center Brooklyn, New York 11203, USA ; The Center for Cardiovascular and Muscle Research, State University of New York, Downstate Medical Center Brooklyn, New York 11203, USA ; The School of Graduate Studies Program in Molecular and Cellular Science, State University of New York, Downstate Medical Center Brooklyn, New York 11203, USA ; Bio-Defense Systems, Inc, Rockville Centre New York 11570, USA ; Orient Biomedica Estero, Florida 33928, USA.

Copyright

(Copyright © 2012, e-Century Publishing)

DOI

unavailable

PMID

22993647

Abstract

Recently, we reported on the discovery of a new, conserved biologic protein (35-40 KDa), termed HDFx, that protects rats, guinea-pigs, mice, and rabbits against lethal hemorrhage, endotoxins, intestinal ischemic-shock, and traumatic injuries. It was found to stimulate several arms of the immune system. The present report demonstrates, for the first time, that HDFx accelerates wound healing in two different models (excision wound model; and incision wound model) in rats. The results shown, herein, indicate that HDFx produces greater rates of wound contraction, greater tensile strength, and more rapid healing than controls. Our new data also show that this biologic increases hydroxyproline content of granulation tissue coupled with a reduction in superoxide dismutase (SOD). In addition, we show that HDFx increases the levels of serum ascorbic acid and stimulates the mononuclear cells of the reticuloendothelial system (RES). Overall, these data suggest that HDFx may possess unique regenerative powers. We, thus, believe that HDFx can be of great potential use in diverse types of wounds which, otherwise, could result in difficult to treat infections and thus prevent sepsis and loss of body parts from amputations.

Language: en