Citation

Lonjon N, Perrin FE, Lonjon M, Fattal C, Segnarbieux F, Privat A, Bauchet L. Neurochirurgie (Paris) 2012; 58(5): 293-299.

Vernacular Title

Les lésions médullaires traumatiques : épidémiologie et perspectives.

Affiliation

Department of neurosurgery, Gui-de-Chauliac Hospital, 80, avenue Augustin-Fliche, 34090 Montpellier, France; Inserm U 1051, pathophysiology and therapy of sensory and motor deficits, Institute for Neurosciences of Montpellier, Saint Eloi Hospital, 34090 Montpellier cedex 05, France.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.neuchi.2012.06.003

PMID

22959585

Abstract

OBJECTIVE: Specify the epidemiological data on the acute spinal cord injuries and define a group of patients that could benefit from cellular transplantation therapy designed with the aim of repair and regeneration of damaged spinal cord tissues. MATERIAL AND METHODS: Five years monocentric (Gui-de-Chauliac Hospital, Montpellier, France) retrospective analysis of patients suffering from spinal cord injury (SCI). Spinal cord injured-patients, defined as sensory-motor complete, underwent a clinical evaluation following American Spinal Injury Association (ASIA) and functional type 2 Spinal Cord Independence Measure (SCIM2) scorings as well as radiological evaluation through spinal cord magnetic resonance imaging (MRI). RESULTS: One hundred and fifty-seven medical records were reviewed and we selected and re-examined 20 patients with complete thoracic spinal cord lesion. Clinical and radiological evaluations of these patients demonstrated, in 75 % of the cases, an absence of clinical progression after a mean of 49months. Radiological abnormalities were constantly present in the initial (at the admission to hospital) and control (re-evaluation) MRI and no reliable predictive criteria of prognosis had been found. DISCUSSION/CONCLUSION: We compare our results to the literature and discuss advantages and limits of cellular transplantation strategies for these patients.

Language: fr