Citation

Mounier B, Pons B, Delavenne X, Beyens MN, Rémy C, Zeni F, Mismetti P, Basset T. Therapie 2012; 67(2): 183-189.

Vernacular Title

Intoxications graves au méprobamate : description d'une série de 146 cas dans le département de la Loire.

Affiliation

Urgences Médico-chirurgicales, Hôpital Nord, CHU, Saint-Étienne, France.

Copyright

(Copyright © 2012, John Libbey Eurotext)

DOI

10.2515/therapie/2012019

PMID

22850107

Abstract

Meprobamate poisoning are serious and sometimes fatal. Faced with a potential stop of marketing, we conducted a multicenter retrospective study to assess the severity criteria presented by patients admitted to the ICU for severe meprobamate poisoning, whether with alone form or in combination with aceprometazine. One hundred fourty-six patients have been enrolled between January 2005 and June 2011: 38 had a single meprobamate poisoning, 104 to meprobamate and aceprometazine and 4 to both forms. At admission, 88% of patients exhibited coma (Glasgow ≤ 7) and half of them a systolic blood pressure ≤90 mmHg. Mortality rate was 3%. Our results did not find any significant between-group difference, either in regard of clinical or biological severity criteria. These data argue for a cessation of marketing of all meprobamate-based specialities.

Language: fr