Citation

Badia-Elder NE, Gilpin NW, Stewart RB. Peptides 2007; 28(2): 339-344.

Affiliation

Department of Psychology, Indiana University Purdue University at Indianapolis (IUPUI), 402 N. Blackford Street, LD 124, Indianapolis, IN 46202, United States. nbadiael@iupui.edu

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/j.peptides.2006.07.028

PMID

17187900

Abstract

Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2h/day. However, when rats undergo chronic (24h/day) ethanol drinking (or exposure to ethanol by vapor inhalation) and have periods of imposed ethanol abstinence, the reductions in ethanol drinking following NPY administration are enhanced in alcohol-preferring rats and are also observed in unselected Wistar rats. Thus, sensitivity to the effects of NPY on ethanol drinking appears to be altered by selective breeding for ethanol preference and by a prior history of chronic but intermittent exposure to ethanol.

Language: en