Citation

Deptula D, Pomara N. J. Clin. Psychopharmacol. 1990; 10(2): 105-111.

Affiliation

Geriatric Psychiatry Center, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.

Copyright

(Copyright © 1990, Lippincott Williams and Wilkins)

DOI

unavailable

PMID

2187911

Abstract

Despite widespread use of antidepressants, major gaps remain in our knowledge of the effects of antidepressants on human performance. While most single-dose studies with normal subjects have suggested that the more sedating tricyclic antidepressants tend to produce impairment, the effects of antidepressant treatment in clinical populations have been less thoroughly examined, with both drug-induced impairment and improvement reported. This review suggests that factors such as age, diagnosis, drug plasma concentration, and length of treatment need to be explored to establish the effects of antidepressants on performance in clinical populations.

Language: en