Citation

Tomita M, Okuyama T, Shimosato K, Kondo Y, Ijiri I. Toxicol. Lett. 1990; 50(2-3): 151-157.

Affiliation

Department of Legal Medicine, Kawasaki Medical School, Kurashiki, Japan.

Copyright

(Copyright © 1990, Elsevier Publishing)

DOI

unavailable

PMID

2309234

Abstract

The effect of ethanol on fatal carbon monoxide (CO) poisoning was investigated in mice injected intraperitoneally with ethanol. Ethanol (1.5 and 3.0 g/kg) was injected 15 min prior to exposure to gas containing 6.6% CO. The survival period was significantly lengthened with ethanol in proportion to the doses injected, although the carboxyhemoglobin (CO-Hb) saturation level in postmortem blood was almost the same in all groups. On the other hand, the CO-Hb level in the blood of mice injected with ethanol was significantly lower than that of control mice during the early exposure period when all mice were still alive. Our results showed that the acute ethanol injection did not influence the CO-Hb saturation level in blood at death, but did affect the duration of survival, probably because of ethanol's ability to decrease blood flow and CO intake.

Language: en