Citation

Paoloni R, Szekely I. Emerg. Med. (ACEM-ASEM) 2002; 14(1): 109-112.

Affiliation

Department of Emergency Medicine, Concord Repatriation General Hospital, New South Wales, Australia. richard.paoloni@email.cs.nsw.gov.au

Copyright

(Copyright © 2002, John Wiley and Sons)

DOI

unavailable

PMID

11993828

Abstract

Bupropion hydrochloride (Zyban, Glaxo Wellcome Australia, Melbourne, Vic., Australia) was released in Australia in November 2000 as adjunctive therapy to assist with smoking cessation, having previously been used as an antidepressant in the US since 1989. The toxicity profile of bupropion hydrochloride in overdose differs considerably from other antidepressants, with prominent neurological manifestations and little cardiovascular toxicity. A case of bupropion overdose demonstrating the typical toxic syndrome is presented, together with a review of the literature and a discussion of the magnitude of the demand for bupropion and of the potential differences in presentation of overdoses in Australia.

Language: en