Citation

Yokoi K, Konomi A. Regul. Toxicol. Pharmacol. 2012; 63(2): 291-297.

Affiliation

Department of Human Nutrition, Seioku University Graduate School, Matsudo, Chiba 271-8555, Japan; Department of Life and Culture, Seitoku University Faculty of Humanities, Matsudo, Chiba 271-8555, Japan.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.yrtph.2012.04.006

PMID

22561181

Abstract

The UK Food Standards Agency and its counterparts in other countries have warned consumers not to eat hijiki (Sargassum fusiforme; synonym Hizikia fusiformis), a Sargasso seaweed, because it contains large amounts of inorganic arsenic. We investigated dietary exposure of hijiki in weaning male F344/N rats fed an AIN-93G diet supplemented with 3% (w/w) hijiki powder for 7weeks, compared with those fed only an AIN-93G diet. Body weight, body temperature, blood and tissue arsenic concentrations, plasma biochemistry and hematological parameters were measured. We found that feeding rats a 3% hijiki diet led to a marked accumulation of arsenic in blood and tissues, and evoked a high body temperature and abnormal blood biochemistry including elevated plasma alkaline phosphatase activity and inorganic phosphorus, consistent with arsenic poisoning. These findings should prompt further investigations to identify the health hazards related to consumption of hijiki and related Sargassum species in humans.

Language: en