Citation

Bischoff-Ferrari HA. Scand. J. Clin. Lab. Invest. Suppl. 2012; 243: 3-6.

Affiliation

Center on Aging and Mobility, University of Zurich and City Hospital Waid Swiss National Foundations Professor, Dept. of Rheumatology, University Hospital , Zurich Switzerland.

Copyright

(Copyright © 2012, Informa - Taylor and Francis Group)

DOI

10.3109/00365513.2012.681938

PMID

22536756

Abstract

Vitamin D deficiency is prevalent in about 50 % of adults and limited data support a similar prevalence in children. This is of concern, as vitamin D deficiency is a risk factor for falls and fractures and several double-blind RCTs provide evidence that supplementation reduces the risk of fall and fractures among the senior population. Further, large epidemiologic studies consistently report that vitamin D deficiency confers an increased risk of mortality, cardiovascular disease and cancer, especially colo-rectal cancer. However, as large clinical trials for non-musculoskeletal endpoints are missing today, public health recommendations are based primarily on bone health to argue vitamin D repletion in the population.

Language: en