Citation

Alebiowu G, Itiola O. Acta Pharm. 2007; 57(1): 73-86.

Copyright

(Copyright © 2007, Versita)

DOI

10.2478/v10007-007-0006-8

PMID

unavailable

Abstract

A 2 3 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration ( c ) and relative density of tablet ( d ) on the disintegration time ( DT ) and dissolution times, t 1 , t 50 and t 90 , of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e. , N, c and d. In general, the most common ranking of the individual effects on DT , t 1 , t 50 and t 90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N- c > c-d > N- d for all formulations. The results generally showed that c can considerably affect DT, t 1 , t 50 and t 90 of the tablets.