Citation

Gyllenberg D, Sourander A, Helenius H, Sillanmaki L, Huttunen J, Piha J, Kumpulainen K, Tamminen T, Moilanen I, Almqvist F. Pharmacoepidemiol. Drug Saf. 2012; 21(9): 964-971.

Affiliation

Department of Child Psychiatry, University of Helsinki and Helsinki University Central Hospital, Finland; Department of Child Psychiatry, University of Turku and Turku University Central Hospital, Finland. david.gyllenberg@helsinki.fi.

Copyright

(Copyright © 2012, John Wiley and Sons)

DOI

10.1002/pds.3265

PMID

22473622

Abstract

OBJECTIVE: Information on who uses antipsychotic medication is limited to cross-sectional data. The objective of this study was to study the patterns of psychopathology at age 8 years and antipsychotic use between the ages of 12 and 25 years. METHODS: A total of 5525 subjects from the Finnish Nationwide 1981 birth cohort were linked to the National Prescription Register and the Hospital Discharge Register between 1994 and 2005. Information about parent-reported and teacher-reported conduct, hyperkinetic and emotional symptoms, and self-reported depressive symptoms was gathered at age 8 years. Information about antipsychotic use and about psychiatric disorders treated in hospitals between the ages of 12 and 25 years was register based. Diagnostic classes of hospital treatment included non-affective psychoses, affective disorders, and other psychiatric disorders. RESULTS: The cumulative incidence of antipsychotic use by age 25 years was 2.8% among men (n = 69) and 2.1% among women (n = 55). In both sexes, living with other than two biological parents at age 8 years was associated with antipsychotic use, and three fourths of antipsychotic users had been treated for psychiatric disorders in a hospital. Among men, the most common hospital diagnosis was non-affective psychoses (44% of all antipsychotic users), and antipsychotic use was associated with childhood conduct problems. Among women, the most common hospital diagnosis was affective disorders (38% of all antipsychotic users), and antipsychotic use was associated with emotional problems and self-reported depressive symptoms in childhood. CONCLUSIONS: Antipsychotic use in adolescence and young adulthood is different among men versus women both with regard to hospital diagnoses and childhood psychiatric problems. Copyright © 2012 John Wiley & Sons, Ltd.

Language: en