Citation

North SH, Shriver-Lake LC, Taitt CR, Ligler FS. Annu. Rev. Anal. Chem. (Palo Alto Calif) 2012; 5: 35-56.

Affiliation

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348; email: stella.north@nrl.navy.mil.

Copyright

(Copyright © 2012, Annual Reviews)

DOI

10.1146/annurev-anchem-062011-143105

PMID

22462400

Abstract

Traumatic brain injury (TBI) results from an event that causes rapid acceleration and deceleration of the brain or penetration of the skull with an object. Responses to stimuli and questions, loss of consciousness, and altered behavior are symptoms currently used to justify brain imaging for diagnosis and therapeutic guidance. Tests based on such symptoms are susceptible to falsepositive and false-negative results due to stress, fatigue, and medications. Biochemical markers of neuronal damage and the physiological response to that damage are being identified. Biosensors capable of rapid measurement of such markers in the circulation offer a solution for on-site triage, as long as three criteria are met: (a) Recognition reagents can be identified that are sufficiently sensitive and specific, (b) the biosensor can provide quantitative assessment of multiple markers rapidly and simultaneously, and (c) both the sensor and reagents are designed for use outside the laboratory. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 5 is June 15, 2012. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

Language: en