Citation

Folland DS, Schaffner W, Ginn HE, Crofford OB, McMurray DR. J. Am. Med. Assoc. JAMA 1976; 236(16): 1853-1856.

Copyright

(Copyright © 1976, American Medical Association)

DOI

unavailable

PMID

989535

Abstract

Fourteen workers in an isopropyl alcohol packaging plant became ill after accidental exposure to carbon tetrachloride. In four, renal failure or hepatitis developed. Isopropyl alcohol potentiation of carbon tetrachloride toxicity has been shown previously only in rats. Acetone, a product of isopropyl alcohol metabolism, is a major potentiator of carbon tetrachloride toxicity. Workers had elevated levels of acetone in samples of expired alveolar gas and thus were metabolically predisposed to carbon tetrachloride injury. Stricter limits for industrial carbon tetrachloride exposure should be established where concomitant isopropyl alcohol use occurs.

Language: en