Citation

Bhattacharya SK, Reddy PK, Ghosal S, Singh AK, Sharma PV. J. Pharm. Sci. 1976; 65(10): 1547-1549.

Copyright

(Copyright © 1976, Wiley-Liss)

DOI

unavailable

PMID

988172

Abstract

CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.

Language: en