Citation

Skopichev VG, Prozorovskiĭ VB. Eksp. Klin. Farmakol. 1999; 62(2): 10-11.

Vernacular Title

Distantnye effekty atsetilkholina--zven'ia v patogeneze intoksikatsii

Affiliation

Institute of Physiology, Saint Petersburg University, Russia.

Copyright

(Copyright © 1999, Izo-Vo Meditsina)

DOI

unavailable

PMID

10340119

Abstract

Scanning electron microscopy showed that the capillary endothelial cells of rats poisoned by O,O-dimethyl-O(2,2-dichlorvinyl) phosphate swell and become wrinkled, while some of the cells acquire fenestrae. In 24 h. these changes become weaker. Mass deformity of erythrocytes was seen at the same time and lasted less than 24 h. Since the capillary endothelium and the erythrocytes are devoid of cholinergic innervation but possess cholinoreceptors, the occurring effects may be explained by the distant action of acetylcholine accumulating in the blood in poisoning by cholinestarase inhibitors.

Language: ru