Citation

Archer T, Svensson K, Alricsson M. Acta Neurol. Scand. 2012; 125(5): 293-302.

Affiliation

Department of Psychology, University of Gothenburg, Gothenburg, Sweden; School of Education, Psychology and Sport Science, Linnaeus University, Kalmar, Sweden.

Copyright

(Copyright © 2012, John Wiley and Sons)

DOI

10.1111/j.1600-0404.2011.01638.x

PMID

22233115

Abstract

The extent and depth of traumatic brain injury (TBI) remains a major determining factor together with the type of structural insult and its location, whether mild, moderate or severe, as well as the distribution and magnitude of inflammation and loss of cerebrovascular integrity, and the eventual efficacy of intervention. The influence of exercise intervention in TBI is multiple, ranging from anti-apoptotic effects to the augmentation of neuroplasticity. Physical exercise diminishes cerebral inflammation by elevating factors and agents involved in immunomodulatory function, and buttresses glial cell, cerebrovascular, and blood-brain barrier intactness. It provides unique non-pharmacologic intervention that incorporate different physical activity regimes, whether dynamic or static, endurance or resistance. Physical training regimes ought necessarily to be adapted to the specific demands of diagnosis, type and degree of injury and prognosis for individuals who have suffered TBI.

Language: en