Citation

Arias AJ, Chan G, Gelernter J, Farrer L, Kranzler HR. Am. J. Addict. 2012; 21(1): 5-10.

Affiliation

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut VA CT Healthcare System, West Haven, Connecticut Departments of Psychiatry; Genetics; and Neurobiology, Yale University School of Medicine, New Haven, Connecticut Departments of Medicine; Neurology; Genetics and Genomics; Epidemiology; and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts Department of Genetics and Developmental Biology, University of Connecticut School of Medicine, Farmington, Connecticut.

Copyright

(Copyright © 2012, John Wiley and Sons)

DOI

10.1111/j.1521-0391.2011.00195.x

PMID

22211341

Abstract

Completed suicide and nonfatal suicide-related outcomes (SROs), such as suicidal ideation and attempts, are heritable. A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide. We examined the association of three OPRM1 single nucleotide polymorphisms (SNPs) (rs1799971, rs609148, and rs648893) with SRO in 426 European Americans, using GEE logistic regression analysis to examine the association of a lifetime history of SRO. There was no allelic association with the SRO phenotypes. A larger sample may be needed to identify risk variants that convey SRO risk. OPRM1 may not be important in the risk of SRO. (Am J Addict 2011;21:5-10).

Language: en