Citation

Desquilbet L, Meyer L. Rev. Epidemiol. Sante Publique 2005; 53(1): 51-68.

Vernacular Title

Variables dependantes du temps dans le modele de Cox Theorie et pratique.

Affiliation

INSERM-INED U569, Service d'Epidémiologie, Hôpital de Bicêtre, 82, rue du Général-Leclerc, 94276 Le Kremlin-Bicêtre. desquilbet@vjf.inserm.fr

Copyright

(Copyright © 2005, Elsevier Publishing)

DOI

unavailable

PMID

15888990

Abstract

In survival analysis, exposure that appears or changes during the follow-up of subjects must be taken into account as a time-dependent covariate in the Cox proportional hazards model. Two types of time-dependent covariates are defined: covariates with unique change, and covariates with multiple changes. The way of taking into account such changes in the exposure is presented in theory and illustrated from a small sample of 5 subjects enrolled in a French HIV cohort. The problems raised by missing data as well as alternative but more sophisticated solutions are also evocated. Annexes include programs for SAS software, and results from the "Log" and "Results" windows.

Language: fr